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LEAD AND METHYL MERCURY: EFFECTS OF ACUTE EXPOSURE ON CYTOCHROME P-450 AND THE MIXED FUNCTION OXIDASE SYSTEM IN THE LIVER

机译：铅和甲基汞：急性接触对肝脏中细胞色素P-450和混合功能氧化酶系统的影响

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The rat liver mixed function oxidase system which is responsible for the metabolism of endogenous and exogenous compounds has been shown to be affected by lead and methyl mercury. Administration of these environmental pollutants to rats results in a decrease in cytochrome P-450 content and inhibition of in vitro N-demethylase and hydroxylase activities. The in vitro enzyme-inhibiting effects of the metals found pharmacological expression in the whole animal by prolongation of hexobarbital-induced sleeping times.

机译：已经证明负责内源性和外源性化合物代谢的大鼠肝脏混合功能氧化酶系统受铅和甲基汞的影响。向大鼠施用这些环境污染物会导致细胞色素P-450含量降低，并抑制体外N-脱甲基酶和羟化酶活性。这些金属的体外酶抑制作用通过延长己糖巴比妥诱导的睡眠时间在整个动物中得到了药理学表达。

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Alvares, Alvito P.; Leigh, Susan; Cohn, Jonathan; Kappas, Attallah;
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年度 1972
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正文语种 {"code":"en","name":"English","id":9}
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1. LEAD AND METHYL MERCURY: EFFECTS OF ACUTE EXPOSURE ON CYTOCHROME P-450 AND THE MIXED FUNCTION OXIDASE SYSTEM IN THE LIVER [J] . Alvito P. Alvares, Susan Leigh, Jonathan Cohn, The Journal of Experomental Medicine . 1972,第6期

机译：铅和甲基汞：急性接触对肝脏中细胞色素P-450和混合功能氧化酶系统的影响
2. The binding of metyrapone to cytochrome P-450 and its inhibitory action on liver microsomal mixed-function oxidase reactions [J] . A G Hildebrandt The biochemical journal . 1971,第2期

机译：甲吡酮与细胞色素P-450的结合及其对肝微粒体混合功能氧化酶反应的抑制作用
3. Growth hormone and drug metabolism. Acute effects on microsomal mixed-function oxidase activities in rat liver [J] . J T. Wilson, T C. Spelsberg The biochemical journal . 1976,第2期

机译：生长激素和药物代谢。对大鼠肝脏微粒体混合功能氧化酶活性的急性影响
4. Effect of deficiency of cytochrome C oxidase assembly peptide cox17p on mitochondrial functions and respiratory-chain in mice [C] . Yoshinori Takahashi, Koichiro Kako, Hidenori Arai, the International Peptide Symposium . 2001

机译：细胞色素C氧化酶组装肽COX17P对小鼠线粒体功能和呼吸链的影响
5. MODIFICATION OF MEMBRANE LIPID COMPOSITION AND MIXED-FUNCTION OXIDASES IN MOUSE LIVER MICROSOMES BY DIETARY TRANS FATTY ACIDS (CYTOCHROME P-450, P-448). [D] . ENIG, MARY GERTRUDE. 1984

机译：饮食跨脂肪酸对小鼠肝微粒体中膜脂成分和混合功能氧化酶的修饰（细胞色素P-450，P-448）。
6. LEAD AND METHYL MERCURY: EFFECTS OF ACUTE EXPOSURE ON CYTOCHROME P-450 AND THE MIXED FUNCTION OXIDASE SYSTEM IN THE LIVER [O] . Alvito P. Alvares, Susan Leigh, Jonathan Cohn, 1972

机译：铅和甲基汞：急性接触对肝细胞色素P-450和混合功能氧化酶系统的影响
7. The binding of metyrapone to cytochrome P-450 and its inhibitory action on liver microsomal mixed-function oxidase reactions. [O] . Hildebrandt, A G 1971

机译：甲吡酮与细胞色素P-450的结合及其对肝微粒体混合功能氧化酶反应的抑制作用。
8. Influence of Cytochrome P450 Mixed-Function Oxidase Induction on the Acute Toxicity to Rainbow Trout 'Salmo gairdner' of Primary Aromatic Amines [R] . Hermens, J. L. M., Bradbury, S. P., Broderius, S. J. 1990

机译：细胞色素p450混合功能氧化酶诱导对初级芳香胺对虹鳟'salmo gairdner'急性毒性的影响

LEAD AND METHYL MERCURY: EFFECTS OF ACUTE EXPOSURE ON CYTOCHROME P-450 AND THE MIXED FUNCTION OXIDASE SYSTEM IN THE LIVER

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